What is Combivir?
Combivir contains a combination of lamivudine and zidovudine. Lamivudine and zidovudine are antiviral drugs. They belong to a group of medicines for the human immunodeficiency virus (HIV) called reverse transcriptase inhibitors. This medicine helps to prevent the reproduction of HIV in the body. Combivir is used to treat HIV that causes acquired immune deficiency syndrome (AIDS). Combivir can also be used for other purposes not mentioned in this medicine guide.
Important information about Combivir
Combivir should not be taken at the same time as other medicines containing either of these two medicines. This includes Epivir, Retrovir, Epzicom (abacavir and lamivudine) and Trizivir (abacavir, lamivudine, zidovudine). Tell your doctor before using Combivir if you have kidney disease, liver disease, pancreatic disorder, bone marrow depression or muscle problems.
Combivir can lower blood cells in the body, which helps fight infections. This can make bleeding easier due to injury or illness due to being around other people. To make sure that the blood cells do not fall too low; your blood will need to be tested regularly.
Patients with hepatitis B may have liver symptoms after stopping Combivir, even months after stopping it. Your doctor may check your liver function regularly for several months after stopping Combivir. Don’t miss scheduled visits.
Some people have experienced a life-threatening condition called lactic acidosis while taking Combivir. Early symptoms of lactic acidosis usually get worse over time, and the condition can be fatal. Get immediate medical attention if you even have mild symptoms of lactic acidosis, such as muscle pain or weakness, numbness or a cold in the arms and legs, breathing problems, abdominal pain, nausea with vomiting, slow or uneven heartbeat, dizziness or very feeling weakness or tired.
Before using Combivir
Combivir should not be taken at the same time as other medicines containing either of these two medicines.
If you have certain conditions, you may need to adjust your dose or special tests to take this medicine safely. Tell your doctor before using Combivir if:
- kidney disease;
- liver disease (including hepatitis);
- inflammation of the pancreas;
- bone marrow suppression
Some people have experienced a life-threatening condition called lactic acidosis while taking Combivir. You may be more likely to get lactic acidosis if you are overweight or have liver disease, are a woman or if you have been taking certain anti-HIV or AIDS medicines for a long time. Talk to your doctor about individual risk.
FDA pregnancy category C, It is not known if this medicine is harmful to the unborn child. Tell your doctor before using Combivir if you are pregnant or plan to become pregnant during treatment. HIV can be transmitted to a child if the mother is not properly treated during pregnancy. Take all anti-HIV medication to control infection during pregnancy.